The REPURPOSED THERAPEUTICS, INC. principal address is 324 S. HYDE PARK AVENUE, SUITE 350, TAMPA, FL, 33606. Therapeutics with particularly high potential efficacy for repurposing include camostat mesylate, remdesivir, favipiravir, tocilizumab, baricitinib, convalescent plasma, and humanized monoclonal antibodies. The drug in question, bucillamine, is an anti-rheumatic, anti-inflammatory drug that has been used in Japan and South Korea to treat rheumatoid arthritis for more than 30 years. 10 We have recently described a potential framework for the identification of repurposed therapeutics. Frontera, a professor of neurology at the NYU Langone Grossman School of Medicine, believes it is time to explore more logistic repurposed medications to treat COVID-19, citing off-brand benefits of medications, such as nortriptyline, to treat associated headaches. 120. Repurposed Therapeutics corporate office is located in 324 S Hyde Park Ave, Ste 350, Tampa, Florida, 33606, United States and has 18 employees. Despite the large repertoire of anticancer agents, there is a need for a robust and targeted anticancer drug with fewer side effects and less prone to drug resistance. 1004. Patients fail to get proper care, diagnosis and treatment. Repurposed Therapeutics, Inc. 70 At its core, this approach involved several principles including a strong mapping on . Pioneering a new era in asthma control Areteia Therapeutics is a new biotechnology company committed to putting asthma patients in better control of their diseaseand back in control of their lives with the first potential oral drug for eosinophilic asthma. The Drug Repurposing Hub is a curated and annotated collection of FDA-approved drugs, clinical trial drugs, and pre-clinical tool compounds with a companion information resource. This can give new life to drugs currently used in the clinic, or shelved drugs that failed initial tests for their main indication. 39 plays 39 0 comments 0. Additional Details: 1000 Ask Question. We do not sell or distribute actual drugs. Two main approaches exist: direct acting antivirals (DAAs) that target viral proteins, and less developed host-targeting agents (HTAs) that inhibit the human host cells that viruses need for replication and spread. Repurposed drugs could offer a rapid route to novel treatments and prophylactics. Segue Therapeutics, LLC (STX) is an early-stage, privately owned bio-technology company located in Louisiana that leverages a proprietary high content imaging platform to discover and commercialize repurposed drugs for human medical conditions that require more effective therapeutic interventions than are currently available, including:. Meanwhile you can send your letters to 324 S. HYDE PARK AVENUE, SUITE 350, TAMPA, FL, 33606. Evaluation of the mechanism of action of established or repurposed cancer therapeutics (previously tested in model organisms and/or humans), spanning small molecule, peptide, protein, cellular, and genetic experimental therapeutics. INSCOP is a trademark of Repurposed Therapeutics, Inc.. The most developed DAA candidates for COVID-19 are repurposed drugs. LA JOLLA, Calif., June 23, 2020 /PRNewswire/ -- Repurpose.AI, an AI drug discovery company, today announced a collaboration with Scripps Research to develop COVID-19 therapeutics. repurposed therapeutics inc defenderpharma.com defender pharma repurposed therapeutics Repurposed Therapeutics's CEO Barry Feinberg Chief Executive Officer & President Future perspectives of drug repurposing in orphan disease therapeutics. Asthma is a major global healthcare problem. The team used artificial intelligence (AI) to uncover 200 approved drugs that have the potential to fight off the SARS-CoV-2 virus. dba Defender Pharmaceuticals, Inc. and Defender SD Manufacturing, LLC Tampa, Florida, United States 78 connections Repurposed Therapeutics's official website is www.defenderpharma.com Background The outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus has spread rapidly around the globe during the past 3 months. Business Approach There are 3 director records in this entity. Find a Lawyer. The current status of the business is Active. Examples include the following: Psoriasis is a condition with a complex pathophysiology and an unmet need for novel effective therapeutics. Repurposed Therapeutics, Inc. ClinicalTrials.gov Identifier: NCT04947423 Other Study ID Numbers: DPI-386-MS-29 : First Posted: July 1, 2021 Key Record Dates: Last Update Posted: September 17, 2021 Last Verified: September 2021 Layout table for additional information . Here, using a computational model of the spike protein (S-protein) of SARS-CoV-2 interacting with the human ACE2 receptor, we make use of the world's most powerful supercomputer, SUMMIT, to enact an ensemble docking . 5. Bucillamine, in Phase III trials in the United States, may be poised to join them. Repurposed drugs became the front-line defense against Covid-19 within a few months of the pandemic's emergence. Clear Search. 15 October 2020. London, UK, 1st September 2020: Relation Therapeutics, a drug development company driven by data science and machine learning (ML), today announces Project RE, which will apply Relation Therapeutics' and its partners' technology to the identification of repurposed drug combinations as potential therapeutic candidates for COVID-19. Solidarity Therapeutics Trial produces conclusive evidence on the effectiveness of repurposed drugs for COVID-19 in record time. Its cannabinoid pharmaceutical portfolio focuses on rare inflammatory areas such as liver disease. Justia Legal Resources. Repurposed Therapeutics, Inc. in Richmond, VT | Company Info & Reviews Company Information Company Contacts BARRY I. FEINBERG Director 324 S. Hyde Park Ave. Suite 350 Tampa, FL 33606 BARRY I. FEINBERG Other Officer W/Policy-Making Authority 324 S. Hyde Park Ave. Suite 350 Tampa, FL 33606 BARRY I. FEINBERG President 350 S. Hyde Park Ave. Suite 350 Drug repurposing is a novel approach that focuses on finding new applications for the old clinically approved drugs. Scripps Research . Revive Therapeutics Advances Repurposed Drug for Mild to Moderate COVID-19 Published: June 16, 2021 By Gail Dutton BioSpace Repurposed drugs became the front-line defense against COVID-19 within a few months of the pandemic's emergence. Repurposed Therapeutics, Inc. is listed as an officer of another company. Lawyers - Get Listed Now! . The repurposing of drugs has become very helpful during the ongoing COVID-19 pandemic as it helps to find low-cost therapeutics in less time . Get the latest business insights from Dun & Bradstreet. Director of Administration, Accounting and Legal, at Repurposed Therapeutics, Ind. Several pharmaceutical companies in collaboration with various academic institutions and governmental organizations have started investigating new therapeutics and repurposing approved drugs so as to find fast and affordable treatments against this disease. highlighted the organizational and regulatory challenges that could impede the advancement of drug repurposing. Conditions in This Trial Motion Sickness Interventions in This Trial DPI-386 Nasal Gel DPI-386 Placebo Nasal Gel Transderm Scop Condition MeSH Term(s) Motion Sickness The emergence and rapid proliferation of the novel coronavirus (SARS-CoV-2) resulted in a global pandemic, with over 6,000,000 cases and nearly 400,000 deaths reported worldwide by the end of May 2020. Abstract. Drug repurposing has been instrumental in drug discovery for rare diseases such as MPM and multiple repositioned small molecule therapies and immunotherapies are currently being tested for its applicability in MPM . Mechanistic and in vitro analyses suggest multiple promising therapeutic options with potential for repurposing to treat patients with COVID-19. Scientific Abstract: Despite global efforts, it took 7 months between the proclamation of global SARS-CoV-2 pandemic and the first FDA-approved treatment for COVID-19. We hypothesize the identified small-molecules may be repurposed to limit viral recognition of host cells and/or disrupt host-virus interactions. A much faster and by far more efficient method for rapidly identifying approved therapeutics that can be repurposed for treating COVID-19 patients is data mining their past and current electronic health and prescription records for identifying drugs that may protect infected individuals from severe COVID-19 symptoms. Owned by: Repurposed Therapeutics, Inc. There are more than 10 ongoing clinical trial studies on remdesivir with repurposed drugs as potential COVID-19 therapeutics ( Table 1 ) ( Figure 3 ). He is most interested in therapeutics or drugs that can be repurposed in humans, which aligns directly with his pharmacotherapeutic interests. The business address is 12935 N 40 Dr Ste 212, Saint Louis, MO 63141-8653, USA. Repurposing Therapeutics for COVID-19: Supercomputer-Based Docking to the SARS-CoV-2 Viral Spike Protein and Viral Spike Protein-Human ACE2 Interface. REPURPOSED THERAPEUTICS, INC. REPURPOSED THERAPEUTICS, INC. has been set up 6/17/2014 in state FL. Now bucillamine, currently in Phase III trials in the U.S., may be poised to join them. Bankruptcy Lawyers; Business Lawyers; According to Frank,. Repurposed Therapeutics, Inc. USPTO Trademarks Repurposed Therapeutics, Inc. Defender Pharmaceuticals Application #88846176 Application Filed: 2020-03-24 Trademark Application Details The mark consists of a shield with two stripes which narrow as they extend upwardly and to the right across the shield. Category: Biomedical Sciences. The company id for this entity is 20246796. Revive Therapeutics Advances Repurposed Drug for Mild to Moderate COVID-19 Published: Jun 16, 2021 By Gail Dutton Repurposed drugs became the front-line defense against COVID-19 within a few months of the pandemic's emergence. Protein-targeted therapeutics are currently unavailable for this virus. The agent name for this entity is: Registered Agent Solutions, Inc.. Defender Pharmaceuticals (DPI, also known as Repurposed Therapeutics) is a pharmaceutical organization focused on the discovery and development of anti-emetic compounds for both the human and veterinary markets. Repurposing therapeutics for malignant pleural mesothelioma (MPM) - Updates on clinical translations and future outlook. Repurposed Therapeutics, Inc. Wright State University Company Website Experience Chief Science Officer Repurposed Therapeutics, Inc. 2013 - Present9 years Dana Point, California Founder, CEO. We hypothesize the identified small-molecules may be repurposed to limit viral recognition of host cells and/or disrupt host-virus interactions. Question: Add details. Get a free directory profile listing. A rush to find a cure prompted re-evaluation of a range of existing therapeutics vis--vis their potential role in treating COVID-19, placing a premium on analytical tools capable of supporting . Mission Matrix Therapeutics is an early-stage, privately owned bio-technology company located in Singapore that leverages a proprietary high content imaging platform to discover and commercialize repurposed drugs for human medical conditions that require more effective therapeutic interventions than are currently available. Ask a Lawyer. The business type is FOREIGN PROFIT CORPORATION. It specializes in the development of scopolamine as a motion sickness countermeasure, specifically in the military and for astronauts. Find a Lawyer. Any repurposed therapeutics found effective in the fight against COVID-19 will face a dramatic increase in demand, and this will put strains on the ability to scale up production. Revive Therapeutics Advances Repurposed Drug for Mild to Moderate Covid-19. As with other coronaviruses, the nucleocapsid (N) protein is the most conserved RNA-binding structural protein of SARS-CoV-2. Known Addresses for Repurposed Therapeutics, Inc. 324 S Hyde Park Ave Tampa, FL 33606 12935 N 40 Dr Saint Louis, MO 63141 2764 Treasure Cove Cir Fort Lauderdale, FL 33312 Corporate Filings for Repurposed Therapeutics, Inc. Florida Department of State Mission. A ranked list of compounds is . . A ranked list of compounds is given that can be tested experimentally. As the virus infected cases and mortality rate of this disease is increasing exponentially, scientists and researchers all over the world are relentlessly working to understand this new virus along with possible treatment regimens by . The Registered Agent on file for this company is Registered Agent Solutions, Inc. and is located at 302 N. Last Chance Gulch Suite 409, Helena, MT 59601. REPURPOSED THERAPEUTICS, INC. was registered on Dec 14 2020 as a foreign profit corporation type with the address 324 S. HYDE PARK AVENUE, SUITE 350, TAMPA, FL, 33606, USA. Identifying coronavirus drug targets. The COVID-19 pandemic continues to pose an unprecedented threat to global public health, having now caused more . Repurposing Therapeutics for COVID-19: Supercomputer-Based Docking to the SARS-CoV-2 Viral Spike Protein and Viral Spike . Scopolamine intranasal - Repurposed Therapeutics Alternative Names: DPI-386; INSCOP spray; Scopolamine HBr - Repurposed Therapeutics Latest Information Update: 28 Sep 2021. Repurposed therapeutics for treatment of JC polyomavirus infection. Serial Number: 88846381. Working Paper . The cardiac MPS rapidly determined the cardiac safety of potential COVID-19 therapeutics, ultimately accelerating patients' access to safe and effective treatments. As orphan disease affects a small percentage of the population, research and pharma companies face great challenge and burden in developing drugs for its management because of small market potential. Find company research, competitor information, contact details & financial data for Repurposed Therapeutics, Inc. of Saint Louis, MO. Repurposed Therapeutics, Inc. is a Montana Foreign Profit Corporation filed On February 2, 2022. Therapeutics with particularly high potential efficacy for repurposing include camostat mesylate, remdesivir, favipiravir, tocilizumab, baricitinib, convalescent plasma, and humanized monoclonal . Repurposed Therapeutics, Inc. is a business incorporated with Washington State Secretary of State. The company's filing status is listed as Active-Good Standing and its File Number is F1264633. An offshoot of his postdoctoral work is a pending patent for pegylated arginase I, currently used to treat cancers, but now repurposed as a therapeutic for retina and brain conditions involving ischemia. . Repurposed drugs already undergoing clinical tests Cambridge scientists hope to speed up the process for the sake of the world's most pressing current battle. Repurposed Therapeutics's phone number is (813) 864-2570 What is Repurposed Therapeutics's official website? Example: "computer". Drug repurposing evaluates new uses, outside of the original clinical indication, for therapeutics approved by the U.S. Food and Drug Administration (FDA) or in late-stage development. Drug repurposing or repositioning is a strategy of finding new indications for already known marketed drugs used in various clinical settings. Current advances in the high-dimensional multiomics landscape, especially proteomics, genomics, and computational omics-data analysis, have facilitated drug repurposing. To search for an exact match, please use Quotation Marks. The Unified Business Identifier (UBI) is #604680296. While clinical trials are time-consuming, the exponential increase in . Revive Therapeutics Ltd is a life sciences company focused on the research and development of drugs for infectious diseases as well as central nervous system and inflammatory disorders. The available treatment options for psoriasis include topical . Order library plates to screen yourself or collaborate with the Broad Institute's Center for the Development of Therapeutics to see if an existing drug may work . Repurposing of approved therapeutics for psoriasis: current need. Adis is an information provider. Despite global efforts, it took 7 months between the proclamation of global SARS-CoV-2 pandemic and the first FDA-approved treatment for COVID-19. Furthermore, several antimicrobial compounds have also been repurposed for cancer therapeutics, such as repurposing antimicrobial agent Doxorubicin as an anti-tumor agent [ 3 ]. Cancer Price : $50 * Buy Profile. The symposium aims to follow the journey from drug discovery to therapeutic development, providing an overview of our strengths and capabilities in novel and repurposed therapeutics, as well as celebrating achievements and recognising successful researchers in the field from across the university and at all career stages. Now bucillamine, currently in Phase III trials in the U.S., may be poised to join them. Invex Therapeutics Limited (ASX:IXC) is a biopharmaceutical company focused on the repurposing of an already approved drug, Exenatide, for efficacious treatment of neurological conditions derived from or involving raised intracranial pressure, such as Idiopathic Intracranial Hypertension (IIH), acute stroke and traumatic brain injury. During this timeframe, clinicians focused their efforts on repurposing drugs, such as hydroxychloroquine (HCQ) or azithromycin (AZM) to treat hospitalized COVID-19 patients. A rush to find the cures prompted re-evaluation of a range of existing therapeutics vis--vis their potential role in treating COVID-19, placing a premium on analytical tools . Founded: Tampa FL United States (2014) Status: No NME R&D (2014) The hypothesis for proposed studies must be developed using innovative processes to identify the therapeutic/indication pair. Filed in August 10 (2015), the INSCOP covers Nasal spray preparations; Pharmaceutical preparations for the . There is a lack of well-structured treatment strategies for treating psoriasis (Boehncke and Brembilla, 2018). Details. Clinical trials of novel therapeutics for Alzheimer's Disease (AD) have consumed a large amount of time and resources with largely negative results. Provider of Information About this Clinical Study Sponsor Overall Official(s) David Helton, Study Director, Repurposed Therapeutics, Inc. . Repurposed Therapeutics, Inc. ClinicalTrials.gov Identifier: NCT03874130 Other Study ID Numbers: DPI-386-DE-10 : First Posted: March 14, 2019 Key Record Dates: Last Update Posted: February 17, 2020 Last Verified: December 2019 Layout table for additional information . Repurposing drugs already approved by the . Skip to main content Accessibility help We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Camostat mesylate has shown therapeutic potential, likely by preventing viral entry into epithelial cells. NCATS is particularly interested in projects that repurpose existing drugs or biologics (existing therapeutics) that have already begun or completed a Phase I clinical trial. Repurposing existing drugs as novel cancer therapeutic. Therapeutics with particularly high potential efficacy for repurposing include camostat mesylate, remdesivir, favipiravir, tocilizumab, baricitinib, convalescent plasma, and humanized monoclonal . From Avery Bond March 26th, 2021. Due to high failure rates and cost involved in traditional drug development procedures, many pharmaceutical companies are primarily focusing on drug repurposing strategy. The emergence and rapid proliferation of the novel coronavirus (SARS-CoV-2) resulted in a global pandemic, with over six million cases and nearly four hundred thousand deaths reported world-wide by the end of May 2020. News release. Repurposed Therapeutics's headquarters are in 324 S Hyde Park Ave, Ste 350, Tampa, Florida, 33606, United States What is Repurposed Therapeutics's phone number? Repurposed therapeutics with known safety profiles may offer a rapid treatment response against emerging coronavirus strains in the future. Worldwide: 250 million people affected The novel Wuhan coronavirus (SARS-CoV-2) has been sequenced, and the virus shares substantial similarity with SARS-CoV. The progress achieved by the Solidarity Therapeutics Trial shows that large international trials are possible, even during a pandemic, and offer the promise of quickly and reliably . In a comprehensive review, Pushpakom et al. Demand will vary depending on the use of a therapeutic, with a higher demand expected for prophylaxis and mild treatment than for treatment of moderate and severe cases. 241 Utilizing real-world evidence to increase efficiency of randomized controlled trials with application to repurposed therapeutics for COVID-19 - Volume 6 Issue s1. Repurposed Therapeutics, Inc. For profit Phase 3. 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